Friday, December 14, 2007

Another reason not to trust people who shove pills at you

Ladies, your ob-gyn isn't going to tell you this, and neither is your pharmacist.

"...this debate has been going on for years, if not decades, and judging by the last studies given wide exposure a few years ago by the media, the issue seems settled: Oral contraception does not significantly increase the risk of breast cancer.

There's just one problem. According to an analysis in one of the most credible peer-reviewed journals in the country, the Mayo Clinic Proceedings, the risk is real. The study employed an often-used medical research technique called "meta-analysis" that allows researchers to combine data from other studies on the risk to get a larger picture. The result: Premenopausal women who used oral contraceptives prior to having their first child have a 44 percent higher chance of getting cancer than women who didn't use the pill. If they used the pill for more than four years prior to their first full-term pregnancy, the risk increased 52 percent. Chris Kahlenborn, an internist at the Altoona (Pa.) Hospital and the study's lead author, suggests one additional woman in 200 could get breast cancer. Extrapolated throughout the population, that could mean thousands more cases every year. I'd say that's an important story.

The reaction? Nearly total silence. Since it was published more than a year ago, I couldn't find a single reference to it in the archives of the New York Times, Washington Post, Los Angeles Times or this paper. The Associated Press appears not to have covered it. I couldn't find a single mainstream media article about it in a Google search. But stories about other breast cancer risks were plentiful, including one about how sleeping with a night light on can increase your chances of getting breast cancer. The National Institute of Cancer doesn't mention the study on its Web site, but it did detail a 5-year-old study claiming to find no higher risk to pill use. The American Cancer Society also doesn't mention the study and concedes only that "it is still not clear what part" the pill plays in breast cancer. Such guidance, if not deceptive, is certainly incomplete.

"The last word seems to be that the pill is safe," Kahlenborn told me, as he called me with his frustration with being unable to get this important information out to women. "The word basically in the medical community before the study, and it continues to be, is that the pill is quite safe." But the results of his study are disquieting enough that if the pill were just coming out today, the findings would be enough for the Food and Drug Administration to keep it off the market, he said."


Here's the complete article (which does not have a link to the study - does anybody know where to look for it? Steph?)
http://www.chicagotribune.com/news/opinion/chi-oped1203byrnedec03,0,3672465.story

Update: found the link. http://www.mayoclinic.org/news2006-rst/3722.html

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